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Research questionHow can LLMs reliably standardize incomplete biomedical metadata when valid schemas and terms require runtime access?Legacy biomedical records often omit required fields or use terms that do not conform to community standards. Prompt-only LLMs may lack the authoritative schemas and ontology vocabularies needed to determine valid metadata values and formats.
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Retrieval-Augmented Generation
Latest papersRecent research connected to this question, newest first.Automated Standardization of Legacy Biomedical Metadata Using an Ontology-Constrained LLM AgentThe evidence concerns ARMS, an ontology-constrained LLM agent that retrieves CEDAR metadata templates and queries authoritative biomedical terminology services during execution. It was evaluated on 839 legacy Human BioMolecular Atlas Program records against expert-standardized references and compared with a prompt-based approach; the findings are limited to this biomedical metadata setting.research paper · Sep 2, 2026
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