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Research questionHow can protein design models jointly model amino acid sequences and 3D structures without separate autoencoder pretraining?Protein function depends on a coupled relationship between amino acid sequence and three-dimensional structure. Modeling both modalities is difficult, while conventional pipelines first learn latent representations before training a generator.
AI
Evaluation & Benchmarks
Machine Learning
Multimodal Models
Research Paper
Latest papersRecent research connected to this question, newest first.SimpleDesign: A Joint Model for Protein Sequence and Structure CodesignThe source describes a single-stage, data-space model trained on more than 2 million sequence–structure pairs and evaluated on co-design and unconditional sequence/structure generation benchmarks. The supplied evidence is benchmark-based; no experimental validation of generated proteins is described.research paper · Sep 3, 2026
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